Sputum transcriptomics reveal upregulation of IL-1 receptor family members in patients with severe asthma.
Identifieur interne : 000355 ( Main/Exploration ); précédent : 000354; suivant : 000356Sputum transcriptomics reveal upregulation of IL-1 receptor family members in patients with severe asthma.
Auteurs : Christos Rossios [Royaume-Uni] ; Stelios Pavlidis [Royaume-Uni] ; Uruj Hoda [Royaume-Uni] ; Chih-Hsi Kuo [Royaume-Uni] ; Coen Wiegman [Royaume-Uni] ; Kirsty Russell [Royaume-Uni] ; Kai Sun [Royaume-Uni] ; Matthew J. Loza [Royaume-Uni] ; Frederic Baribaud [Royaume-Uni] ; Andrew L. Durham [Royaume-Uni] ; Oluwaseun Ojo [Royaume-Uni] ; Rene Lutter [Pays-Bas] ; Anthony Rowe [Royaume-Uni] ; Aruna Bansal [Royaume-Uni] ; Charles Auffray [France] ; Ana Sousa [Royaume-Uni] ; Julie Corfield [Royaume-Uni] ; Ratko Djukanovic [Royaume-Uni] ; Yike Guo [Royaume-Uni] ; Peter J. Sterk [Pays-Bas] ; Kian Fan Chung [Royaume-Uni] ; Ian M. Adcock [Australie]Source :
- The Journal of allergy and clinical immunology [ 1097-6825 ] ; 2017.
Abstract
Sputum analysis in asthmatic patients is used to define airway inflammatory processes and might guide therapy.
DOI: 10.1016/j.jaci.2017.02.045
PubMed: 28528200
Affiliations:
- Australie, France, Pays-Bas, Royaume-Uni
- Angleterre, Auvergne-Rhône-Alpes, Grand Londres, Hollande-Septentrionale, Rhône-Alpes
- Amsterdam, Londres, Lyon
- Université d'Amsterdam
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Southampton, Southampton, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Medicine, Southampton University, and the NIHR Southampton Respiratory Biomedical Research Unit, University Hospital Southampton, Southampton</wicri:regionArea><wicri:noRegion>Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Guo, Yike" sort="Guo, Yike" uniqKey="Guo Y" first="Yike" last="Guo">Yike Guo</name><affiliation wicri:level="3"><nlm:affiliation>Department of Computing & Data Science Institute, Imperial College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Computing & Data Science Institute, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name 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Janssen Research and Development, High Wycombe, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Computing & Data Science Institute, Imperial College London, London, United Kingdom; Janssen Research and Development, High Wycombe</wicri:regionArea><wicri:noRegion>High Wycombe</wicri:noRegion></affiliation></author><author><name sortKey="Hoda, Uruj" sort="Hoda, Uruj" uniqKey="Hoda U" first="Uruj" last="Hoda">Uruj Hoda</name><affiliation wicri:level="3"><nlm:affiliation>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Kuo, Chih Hsi" sort="Kuo, Chih Hsi" uniqKey="Kuo C" first="Chih-Hsi" last="Kuo">Chih-Hsi Kuo</name><affiliation wicri:level="3"><nlm:affiliation>Department of Computing & Data Science Institute, Imperial College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Computing & Data Science Institute, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Wiegman, Coen" sort="Wiegman, Coen" uniqKey="Wiegman C" first="Coen" last="Wiegman">Coen Wiegman</name><affiliation wicri:level="3"><nlm:affiliation>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Russell, Kirsty" sort="Russell, Kirsty" uniqKey="Russell K" first="Kirsty" last="Russell">Kirsty Russell</name><affiliation wicri:level="3"><nlm:affiliation>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sun, Kai" sort="Sun, Kai" uniqKey="Sun K" first="Kai" last="Sun">Kai Sun</name><affiliation wicri:level="3"><nlm:affiliation>Department of Computing & Data Science Institute, Imperial College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Computing & Data Science Institute, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Loza, Matthew J" sort="Loza, Matthew J" uniqKey="Loza M" first="Matthew J" last="Loza">Matthew J. Loza</name><affiliation wicri:level="1"><nlm:affiliation>Janssen Research and Development, High Wycombe, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Janssen Research and Development, High Wycombe</wicri:regionArea><wicri:noRegion>High Wycombe</wicri:noRegion></affiliation></author><author><name sortKey="Baribaud, Frederic" sort="Baribaud, Frederic" uniqKey="Baribaud F" first="Frederic" last="Baribaud">Frederic Baribaud</name><affiliation wicri:level="1"><nlm:affiliation>Janssen Research and Development, High Wycombe, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Janssen Research and Development, High Wycombe</wicri:regionArea><wicri:noRegion>High Wycombe</wicri:noRegion></affiliation></author><author><name sortKey="Durham, Andrew L" sort="Durham, Andrew L" uniqKey="Durham A" first="Andrew L" last="Durham">Andrew L. 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Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Lutter, Rene" sort="Lutter, Rene" uniqKey="Lutter R" first="Rene" last="Lutter">Rene Lutter</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Medicine, University of Amsterdam, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Faculty of Medicine, University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Rowe, Anthony" sort="Rowe, Anthony" uniqKey="Rowe A" first="Anthony" last="Rowe">Anthony Rowe</name><affiliation wicri:level="1"><nlm:affiliation>Janssen Research and Development, High Wycombe, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Janssen Research and Development, High Wycombe</wicri:regionArea><wicri:noRegion>High Wycombe</wicri:noRegion></affiliation></author><author><name sortKey="Bansal, Aruna" sort="Bansal, Aruna" uniqKey="Bansal A" first="Aruna" last="Bansal">Aruna Bansal</name><affiliation wicri:level="1"><nlm:affiliation>Acclarogen, St John's Innovation Centre, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Acclarogen, St John's Innovation Centre, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Auffray, Charles" sort="Auffray, Charles" uniqKey="Auffray C" first="Charles" last="Auffray">Charles Auffray</name><affiliation wicri:level="3"><nlm:affiliation>European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL, Université de Lyon, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL, Université de Lyon, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Sousa, Ana" sort="Sousa, Ana" uniqKey="Sousa A" first="Ana" last="Sousa">Ana Sousa</name><affiliation wicri:level="1"><nlm:affiliation>Respiratory Therapeutic Unit, GSK, Stockley Park, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Respiratory Therapeutic Unit, GSK, Stockley Park</wicri:regionArea><wicri:noRegion>Stockley Park</wicri:noRegion></affiliation></author><author><name sortKey="Corfield, Julie" sort="Corfield, Julie" uniqKey="Corfield J" first="Julie" last="Corfield">Julie Corfield</name><affiliation wicri:level="1"><nlm:affiliation>AstraZeneca R&D, Molndal, Sweden, and Areteva R&D, Nottingham, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>AstraZeneca R&D, Molndal, Sweden, and Areteva R&D, Nottingham</wicri:regionArea><wicri:noRegion>Nottingham</wicri:noRegion></affiliation></author><author><name sortKey="Djukanovic, Ratko" sort="Djukanovic, Ratko" uniqKey="Djukanovic R" first="Ratko" last="Djukanovic">Ratko Djukanovic</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, Southampton University, and the NIHR Southampton Respiratory Biomedical Research Unit, University Hospital Southampton, Southampton, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Medicine, Southampton University, and the NIHR Southampton Respiratory Biomedical Research Unit, University Hospital Southampton, Southampton</wicri:regionArea><wicri:noRegion>Southampton</wicri:noRegion></affiliation></author><author><name sortKey="Guo, Yike" sort="Guo, Yike" uniqKey="Guo Y" first="Yike" last="Guo">Yike Guo</name><affiliation wicri:level="3"><nlm:affiliation>Department of Computing & Data Science Institute, Imperial College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Computing & Data Science Institute, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sterk, Peter J" sort="Sterk, Peter J" uniqKey="Sterk P" first="Peter J" last="Sterk">Peter J. Sterk</name><affiliation wicri:level="4"><nlm:affiliation>Faculty of Medicine, University of Amsterdam, Amsterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Faculty of Medicine, University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Chung, Kian Fan" sort="Chung, Kian Fan" uniqKey="Chung K" first="Kian Fan" last="Chung">Kian Fan Chung</name><affiliation wicri:level="3"><nlm:affiliation>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Adcock, Ian M" sort="Adcock, Ian M" uniqKey="Adcock I" first="Ian M" last="Adcock">Ian M. Adcock</name><affiliation wicri:level="1"><nlm:affiliation>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, United Kingdom; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia. Electronic address: ian.adcock@imperial.ac.uk.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, United Kingdom; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, Newcastle</wicri:regionArea><wicri:noRegion>Newcastle</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Journal of allergy and clinical immunology</title><idno type="eISSN">1097-6825</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Sputum analysis in asthmatic patients is used to define airway inflammatory processes and might guide therapy.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Pays-Bas</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Auvergne-Rhône-Alpes</li><li>Grand Londres</li><li>Hollande-Septentrionale</li><li>Rhône-Alpes</li></region><settlement><li>Amsterdam</li><li>Londres</li><li>Lyon</li></settlement><orgName><li>Université d'Amsterdam</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Rossios, Christos" sort="Rossios, Christos" uniqKey="Rossios C" first="Christos" last="Rossios">Christos Rossios</name></region><name sortKey="Bansal, Aruna" sort="Bansal, Aruna" uniqKey="Bansal A" first="Aruna" last="Bansal">Aruna Bansal</name><name sortKey="Baribaud, Frederic" sort="Baribaud, Frederic" uniqKey="Baribaud F" first="Frederic" last="Baribaud">Frederic Baribaud</name><name sortKey="Chung, Kian Fan" sort="Chung, Kian Fan" uniqKey="Chung K" first="Kian Fan" last="Chung">Kian Fan Chung</name><name sortKey="Corfield, Julie" sort="Corfield, Julie" uniqKey="Corfield J" first="Julie" last="Corfield">Julie Corfield</name><name sortKey="Djukanovic, Ratko" sort="Djukanovic, Ratko" uniqKey="Djukanovic R" first="Ratko" last="Djukanovic">Ratko Djukanovic</name><name sortKey="Durham, Andrew L" sort="Durham, Andrew L" uniqKey="Durham A" first="Andrew L" last="Durham">Andrew L. Durham</name><name sortKey="Guo, Yike" sort="Guo, Yike" uniqKey="Guo Y" first="Yike" last="Guo">Yike Guo</name><name sortKey="Hoda, Uruj" sort="Hoda, Uruj" uniqKey="Hoda U" first="Uruj" last="Hoda">Uruj Hoda</name><name sortKey="Kuo, Chih Hsi" sort="Kuo, Chih Hsi" uniqKey="Kuo C" first="Chih-Hsi" last="Kuo">Chih-Hsi Kuo</name><name sortKey="Loza, Matthew J" sort="Loza, Matthew J" uniqKey="Loza M" first="Matthew J" last="Loza">Matthew J. Loza</name><name sortKey="Ojo, Oluwaseun" sort="Ojo, Oluwaseun" uniqKey="Ojo O" first="Oluwaseun" last="Ojo">Oluwaseun Ojo</name><name sortKey="Pavlidis, Stelios" sort="Pavlidis, Stelios" uniqKey="Pavlidis S" first="Stelios" last="Pavlidis">Stelios Pavlidis</name><name sortKey="Rowe, Anthony" sort="Rowe, Anthony" uniqKey="Rowe A" first="Anthony" last="Rowe">Anthony Rowe</name><name sortKey="Russell, Kirsty" sort="Russell, Kirsty" uniqKey="Russell K" first="Kirsty" last="Russell">Kirsty Russell</name><name sortKey="Sousa, Ana" sort="Sousa, Ana" uniqKey="Sousa A" first="Ana" last="Sousa">Ana Sousa</name><name sortKey="Sun, Kai" sort="Sun, Kai" uniqKey="Sun K" first="Kai" last="Sun">Kai Sun</name><name sortKey="Wiegman, Coen" sort="Wiegman, Coen" uniqKey="Wiegman C" first="Coen" last="Wiegman">Coen Wiegman</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Lutter, Rene" sort="Lutter, Rene" uniqKey="Lutter R" first="Rene" last="Lutter">Rene Lutter</name></region><name sortKey="Sterk, Peter J" sort="Sterk, Peter J" uniqKey="Sterk P" first="Peter J" last="Sterk">Peter J. Sterk</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Auffray, Charles" sort="Auffray, Charles" uniqKey="Auffray C" first="Charles" last="Auffray">Charles Auffray</name></region></country><country name="Australie"><noRegion><name sortKey="Adcock, Ian M" sort="Adcock, Ian M" uniqKey="Adcock I" first="Ian M" last="Adcock">Ian M. Adcock</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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